There is no established antiviral standard treatment method other than supportive treatment for COVID-19. However, based on limited data, antiviral administration may be attempted at the discretion of the medical staff in charge.
In particular, more aggressively consider antiviral administration to severe patients, patients with a worsening clinical course, and patients at high risk of progression to severe disease (the elderly, chronically ill, immunocompromised, etc.). Even if drug use is attempted for prophylactic purposes, it should be limited to patients judged to be at very high risk.
This is the result of confirming the expert recommendations on drug treatment for COVID-19 announced on the 13th by three societies, the Korean Society for Infectious Diseases, the Korean Society for Antibacterial Therapy, and the Korean Society for Pediatric Infectious Diseases. In the front-line hospital system, it was found that there are many demands from patients who actually want prophylactic administration.
What can antiviral therapy be used?
There have been studies showing that the antimalarial drug chloroquine inhibited virus replication in vitro studies of existing coronaviruses, and studies have been reported that effectively inhibited virus replication in vitro experiments related to COVID-19. Instead, 400 mg of hydroxychloroquine may be administered alone once a day. In the data recently published in Clinical Infectious Diseases, hydroxychloroquine has a much better antiviral effect than chloroquine. The dosage of 400 mg on the first day followed by 200 mg administration for 4 days (total administration for 5 days) is suggested. Buy Ivermectin online can help used for anti virus.
Interferon can be administered in combination with Kaletra. However, in the case of type 1 interferon, the expected effect may be different depending on the time of various diseases (early or late stage of disease), so it is necessary to consider this.
Remdesivir, an Ebola treatment, is currently undergoing clinical trials abroad for patients infected with COVID-19. It can be used after obtaining permission from the Ministry of Food and Drug Safety. However, it can only be used in clinical trials.
Ribavirin for the treatment of hepatitis C is not recommended as a drug with many adverse reactions. However, if it is difficult or ineffective to use the recommended drugs for primary use, combination therapy with Kaletra or interferon may be considered.
Is there any pharmacological treatment that can be applied other than antiviral drugs?
Type 1 interferon monotherapy is not recommended for use in patients with COVID-19. If type 1 interferon is considered, it is recommended to use it as a combination therapy. During combination therapy, the use of type 1 interferon and Kaletra is recommended. Among the types of type 1 interferon, IFN-β1b is recommended as the most preferred therapy for patients with COVID-19.
There are no established studies that steroid use is beneficial for patient treatment, and long-term exposure is associated with several side effects, so routine use is not recommended. However, steroid administration may be considered if other conditions such as exacerbation of asthma or severe septic shock requiring vasopressors are present.
Immunoglobulin therapy (IVIG) is not routinely recommended for the treatment of COVID-19 as there are no studies showing it is helpful in the treatment or prognosis of patients with coronavirus infection. Buy Ivermectin for Humans and Ivermectin 3mg Tablets using for treating viruses.
Routine use of influenza antiviral neuraminidase inhibitors for the treatment of COVID-19 is not recommended. Antiviral drugs may be used if influenza infection is or is strongly suspected of having been combined.
Antibiotics are not recommended for routine use of antibiotics for the treatment of COVID-19. However, antibiotics may be used if a bacterial infection is present or suspected. The type of antibiotic is selected by the medical staff according to the clinical symptoms and condition of the patient.
